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Home
About Us
Advanced Cancer
- Cancer Type
  - Bladder
  - Brain
  - Breast
  - Cervical
  - Colorectal
  - Esophageal
  - GIST
  - Liver
  - Lung
  - Neuroendocrine
  - Melanoma
  - Ovarian
  - Pancreatic
  - Prostate
  - Renal Cell
- If Cancer Spreads
Support
Resources
Health Equity
Donate

2026 Updates coming soon

Metastatic Breast Cancer Treatment Roadmap

1. Receptor Status (Subtype)

HR Status:
HR Positive HR Negative (ER- and PR-) Unknown

HER2 Status:
HER2 Positive HER2 Low (1+ or 2+/FISH-) HER2 Negative (0) Unknown

ER Status:
ER Positive ER Negative Unknown

PR Status:
PR Positive PR Negative Unknown

Triple Negative?
Yes No Unknown

2. Genomic Biomarkers

PIK3CA Mutant ESR1 Mutant AKT1/PTEN Alteration

germline BRCA1/2 PD-L1 Positive (CPS ≥10) NTRK Fusion

3. Prior Treatments (Select All That Apply)

Endocrine/Targeted: CDK4/6 Inhibitor SERD / AI PI3K/AKT Inhibitor

Anti-HER2 / ADCs: Enhertu (T-DXd) Trodelvy Perjeta/Herceptin

Other Treatments/Notes:

4. Primary Site of Metastasis

Bone Only Visceral (Liver/Lung) CNS (Brain) Skin / Soft Tissue Unknown

Do you have any other questions or needs?

Clinical Decision Support Roadmap

The information presented in this Website is not intended as a substitute for medical care. Please talk with your healthcare provider about any information you get from this Website.