Breast Cancer Biomarkers

Biomarkers can help a treatment team to determine the best treatment for a patient, see how the patient is responding, and assist in creating a care plan. New tumor markers are being identified with more frequency, so all tumor markers may not yet be reflected on this list.

The following markers may be helpful for those who are diagnosed with breast cancer.  

  • Ataxia telangiectasia mutation
  • BRCA1 and BRCA2 gene mutations
  •  CA15-3/CA27.29
  • CA 27.29
  • Circulating tumor cells of epithelial origin (CELLSEARCH)
  • CTLA-4
  • DPD gene mutation
  • Driver genes (TP53, ESRI, GATA3, KMT2C, NCORI, AKT1, NF1, RIC8A, and RB1)
  • Estrogen Receptor (ER) and Progesterone Receptor (PR)
  • HER2 gene amplification or overexpression
  • Matrix metalloproteinase-9 (MMP)
  • NTRK gene fusion
  • PIK3CA
  • Phosphatase and tensin homolog (PTEN)
  • Programmed death ligand 1 (PD-L1)
  • TROP2
  • Tumor mutations (ATM, PMS2, CHEK2, ATR, and CDH1)
  • Urokinase plasminogen activator (uPA) and plasminogen   activator inhibitor (PAI-1)
  • 21-Gene signature (Oncotype DX)
  • 70-Gene signature (Mammaprint)