Pancreatic Cancer Biomarkers

Biomarkers can help a treatment team to determine the best treatment for a patient, see how the patient is responding, and assist in creating a care plan. New tumor markers are being identified with more frequency, so all tumor markers may not yet be reflected on this list.

MSI-H also known as dMMR or MMR-D, mismatch repair deficiency

NTRK                                 

MSI-high

Inherited mutation 

BRCA1 or BRCA2                                                   

Tumor Mutational Burden High (TMB-)

  • NTRK 

 

SPARC mRNA expression miRNAs,  expressing high miR-21, miR-1 55 and miR-203; and low miR-34a levels.

Other studies demonstrated that lower expression of miR-494 and miR-218 and high miR-221 and miR-744 predict poor prognosis in pancreatic cancer.

Serum Carbohydrte antigen (CA) 19-9 in Lewis-negative blood type

Adhesion molecules

AGR2
APN/CD13
APOA1
APOA2
APOC1
APOC2
APOE
APOL1
C4BPA 2
C5
CA125
CA242
CAM17.1
cathepsin-D
CEA
CEACAM1
Cofilin-1
CXCL10
CXCL11
DKK1
DUPAN-2
Eotaxin
FGF-10/KGF-2
Fuc-Hpt
Galectin
Glypican-1
GPNMB
HGF
HSP27
ICAM-1
IGFBP-1, IGFBP-2, IGFBP-3
IL-10, IL-11, Il-1B, IL-6, IL-8
IP-10
IL-6
MIC-1/GDF15
IL-11
IP-10
IL-6
MIC-1/GDF15
IL-11
IL-8
IL-10
IL-1β
OSM
TNF-α
M-CSF
CXCL11
SCF
ITIH
Kisspeptin
LAMC2
LOXL2
LRG1
M2-PK
MCP-1
M-CSF
MIC-1/GDF15
MicroRNAs
MMP-12
MMP-7
MMP-9
MSLN
MUC16
MUC5AC
OPG
OSM
Osteonectin
Osteopontin
PAM4
PARK7/DJ-1
PDGF
PRX
REG1A
REG1B
REG4
REGIII
SAA
sCD40L
SCF
sgC1
sTRA, 
SYCN
TFP1 
TGF-B
THBS-1
HBS-2
IMP-1
TNF-a
Trypsinogen-2
TSGF
TTF1
TTF2
TTF3    
TTR
ULBP2
VEGF
YKL-40

Select MDX  HOXC6 and DLX1 mRNATissue Based Biomarkerd