GIST Cancer Biomarkers

Biomarkers can help a treatment team to determine the best treatment for a patient, see how the patient is responding, and assist in creating a care plan. New tumor markers are being identified with more frequency, so all tumor markers may not yet be reflected on this list.

                              Immunohistochemical

  • KIT (CD117)
  • DOG1 (ANO1)
  • SDHB
  • SDHA
  • Molecular (KIT, PDGFRA, BRAF, SDHA/B/C/D, or NF1 mutational analysis)
  • 5 + PDGFRA
  • BRAF
  • ROR2
  • SETD2
  • SDHA/B/C/D
  • NF1
  • Whole tissue section
  • KIT
  • Exons Assessed
  • Exon 9
  • Exon 11
  • Exon 13
  • Exon 14
  • Exon 17
  • PDGFRA Mutational Analysis + Exons
  • Exon 12
  • Exon 14
  • Exon 18
  • SDH A/B/C/D
  • Programmed death ligand 1 (PD-L1)